Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment

Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment

Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process...

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Main Authors: Gang Su, Xiaohong Ma, Haidong Wei
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/5608382
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spelling doaj-483afcd3eb6a4f0d89236a8d98f2b60a2020-11-25T03:49:22ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/56083825608382Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation MicroenvironmentGang Su0Xiaohong Ma1Haidong Wei2Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaLanzhou University Second Hospital, Lanzhou University, Lanzhou, ChinaLanzhou University Second Hospital, Lanzhou University, Lanzhou, ChinaLung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed the mechanism of extracellular vesicles released by blood and airways on lung inflammation. Finally, the role of extracellular vesicles in viral infection of the lung was also described.http://dx.doi.org/10.1155/2020/5608382
collection DOAJ
language English
format Article
sources DOAJ
author Gang Su
Xiaohong Ma
Haidong Wei
spellingShingle Gang Su
Xiaohong Ma
Haidong Wei
Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
BioMed Research International
author_facet Gang Su
Xiaohong Ma
Haidong Wei
author_sort Gang Su
title Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
title_short Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
title_full Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
title_fullStr Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
title_full_unstemmed Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
title_sort multiple biological roles of extracellular vesicles in lung injury and inflammation microenvironment
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2020-01-01
description Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed the mechanism of extracellular vesicles released by blood and airways on lung inflammation. Finally, the role of extracellular vesicles in viral infection of the lung was also described.
url http://dx.doi.org/10.1155/2020/5608382
work_keys_str_mv AT gangsu multiplebiologicalrolesofextracellularvesiclesinlunginjuryandinflammationmicroenvironment
AT xiaohongma multiplebiologicalrolesofextracellularvesiclesinlunginjuryandinflammationmicroenvironment
AT haidongwei multiplebiologicalrolesofextracellularvesiclesinlunginjuryandinflammationmicroenvironment
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