Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells

Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells

Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1, 1, 10, 50, and 100 μg/m...

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Bibliographic Details
Main Authors: Alix Barbe, Christelle Ramé, Namya Mellouk, Anthony Estienne, Alice Bongrani, Adeline Brossaud, Antonella Riva, Fabrice Guérif, Pascal Froment, Joëlle Dupont
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
human granulosa cells
grape seed extract
oxidative stress
steroidogenesis
cell signaling
apoptosis
Online Access:https://www.mdpi.com/1422-0067/20/17/4215

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