Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide

In contrast to the well-established palladium-catalyzed version, the nickel-catalyzed carbonylative coupling is underdeveloped. Here the authors report a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagents, allowing for preparation of β,γ-unsaturated ketones in a linear-selectiv...

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Main Authors:	Yangyang Weng, Chenhuan Zhang, Zaiquan Tang, Mohini Shrestha, Wenyi Huang, Jingping Qu, Yifeng Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14320-1

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record_format	Article
spelling	doaj-48391b364a9c447590575e70c4ce619c2021-05-11T08:08:13ZengNature Publishing GroupNature Communications2041-17232020-01-011111910.1038/s41467-020-14320-1Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanideYangyang Weng0Chenhuan Zhang1Zaiquan Tang2Mohini Shrestha3Wenyi Huang4Jingping Qu5Yifeng Chen6Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and TechnologyIn contrast to the well-established palladium-catalyzed version, the nickel-catalyzed carbonylative coupling is underdeveloped. Here the authors report a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagents, allowing for preparation of β,γ-unsaturated ketones in a linear-selective fashion.https://doi.org/10.1038/s41467-020-14320-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yangyang Weng Chenhuan Zhang Zaiquan Tang Mohini Shrestha Wenyi Huang Jingping Qu Yifeng Chen
spellingShingle	Yangyang Weng Chenhuan Zhang Zaiquan Tang Mohini Shrestha Wenyi Huang Jingping Qu Yifeng Chen Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide Nature Communications
author_facet	Yangyang Weng Chenhuan Zhang Zaiquan Tang Mohini Shrestha Wenyi Huang Jingping Qu Yifeng Chen
author_sort	Yangyang Weng
title	Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
title_short	Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
title_full	Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
title_fullStr	Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
title_full_unstemmed	Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
title_sort	nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	In contrast to the well-established palladium-catalyzed version, the nickel-catalyzed carbonylative coupling is underdeveloped. Here the authors report a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagents, allowing for preparation of β,γ-unsaturated ketones in a linear-selective fashion.
url	https://doi.org/10.1038/s41467-020-14320-1
work_keys_str_mv	AT yangyangweng nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT chenhuanzhang nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT zaiquantang nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT mohinishrestha nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT wenyihuang nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT jingpingqu nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide AT yifengchen nickelcatalyzedallyliccarbonylativecouplingofalkylzincreagentswithtertbutylisocyanide
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Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide

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