Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex

Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex

The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. The channel forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of the five members of the KCNE family, binds to Kv1.3, altering channel activity and membrane expression. The...

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Bibliographic Details
Main Authors: Laura Solé, Daniel Sastre, Magalí Colomer-Molera, Albert Vallejo-Gracia, Sara R. Roig, Mireia Pérez-Verdaguer, Pilar Lillo, Michael M. Tamkun, Antonio Felipe
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
potassium channels
immune system
oligomeric complex
regulatory subunits
Online Access:https://www.mdpi.com/2073-4409/9/5/1128

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