Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg‐Calvé‐Perthes Disease and Correlation With IL‐6

ABSTRACT Legg‐Calvé‐Perthes disease (LCPD) is a childhood ischemic osteonecrosis (ON) of the femoral head associated with the elevation of proinflammatory cytokine interleukin‐6 (IL‐6) in the synovial fluid. Currently, there is no effective medical therapy for patients with LCPD. In animal models of...

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Bibliographic Details
Main Authors: Nobuhiro Kamiya, Harry KW Kim
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10429