Improvement of the Effectiveness of Antiviral Treatment of Patients with Chronic Hepatitis C and Concomitant Diabetes Mellitus Type II using Alpha-Lipoic Acid and Lactulose

• Main Authors: Oleksandra Marynchak, Oleksandra Pryshliak, Oleksandr Boichuk, Olga Prokofieva
• Format: Article
• Language: English
• Published: Ivano-Frankivsk National Medical University 2016-11-01
• Series: Galician Medical Journal
• Subjects: chronic hepatitis c; viral load; cytokines; diabetes mellitus
• Online Access: https://ifnmujournal.com/gmj/article/view/679
• ISSN: 2414-1518

Imbalance of pro-inflammatory and anti-inflammatory cytokines was detected in 104 examined the patients with chronic hepatitis C. These changes were the most significant in patients with concomitant diabetes mellitus (DM) type II. Achievement of sustained viral response (SVR) under the influence of antiviral therapy depends on the state of cytokines system. This was evidenced by the detected correlation relationship between the levels of viral load (VL) in patients with concomitant diabetes mellitus type II, namely, direct weak one between IL-4 and VL (r=0.21) and reverse weak one between the level of IL-2 and VL (r=-0.04). Virus elimination rate and frequency influenced by anti-viral therapy (AVT) depends on the balance of pro-inflammatory and anti-inflammatory cytokines. This was shown in the research by detection of direct medium correlation relationship between VL and IL-4 (r= 0.31) and reverse medium correlation relationship between VL and IL-2 (r= -0.45).