The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells

The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells

Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, doubl...

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Bibliographic Details
Main Author: Pier Adelchi Ruffini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
CXCR1
CXCL8
cancer stem-like cells
reparixin
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00040/full
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spelling doaj-4823893a4b11475a84621d0f4e924eaa2020-11-24T21:47:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-02-01910.3389/fonc.2019.00040433657The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like CellsPier Adelchi RuffiniCancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.https://www.frontiersin.org/article/10.3389/fonc.2019.00040/fullCXCR1CXCL8cancer stem-like cellsreparixinbreast cancer
collection DOAJ
language English
format Article
sources DOAJ
author Pier Adelchi Ruffini
spellingShingle Pier Adelchi Ruffini
The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
Frontiers in Oncology
CXCR1
CXCL8
cancer stem-like cells
reparixin
breast cancer
author_facet Pier Adelchi Ruffini
author_sort Pier Adelchi Ruffini
title The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_short The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_full The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_fullStr The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_full_unstemmed The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_sort cxcl8-cxcr1/2 axis as a therapeutic target in breast cancer stem-like cells
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2019-02-01
description Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.
topic CXCR1
CXCL8
cancer stem-like cells
reparixin
breast cancer
url https://www.frontiersin.org/article/10.3389/fonc.2019.00040/full
work_keys_str_mv AT pieradelchiruffini thecxcl8cxcr12axisasatherapeutictargetinbreastcancerstemlikecells
AT pieradelchiruffini cxcl8cxcr12axisasatherapeutictargetinbreastcancerstemlikecells
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