The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression

The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression

Neuroblastoma (NB), which arises from embryonic neural crest cells, is the most common extra-cranial solid tumor of childhood. Approximately half of NB patients manifest bone metastasis accompanied with bone pain, fractures and bone marrow failure, leading to disturbed quality of life and poor survi...

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Bibliographic Details
Main Authors: Takahiro Tsutsumimoto, Paul Williams, Toshiyuki Yoneda
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Journal of Bone Oncology
Subjects:
Osteoclasts
Receptor activator of NF-κB ligand
Vascular endothelial growth factor-A
Microvessel density
Adrenal gland
COX-2 inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S221213741420008X

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http://www.sciencedirect.com/science/article/pii/S221213741420008X

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