Body-Weight Fluctuation Was Associated With Increased Risk for Cardiovascular Disease, All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis

• Main Authors: Huajie Zou, Ping Yin, Liegang Liu, Wenhua Liu, Zeqing Zhang, Yan Yang, Wenjun Li, Qunchuan Zong, Xuefeng Yu
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-11-01
• Series: Frontiers in Endocrinology
• Subjects: body-weight fluctuation; weight cycling; mortality; CVD; meta-analysis
• Online Access: https://www.frontiersin.org/article/10.3389/fendo.2019.00728/full
• ISSN: 1664-2392

Background: The aim of this study was to evaluate associations between body-weight fluctuation and risk of mortality and cardiovascular diseases (CVD).Methods: PubMed, EMBASE databases and Cochrane Library were searched for cohort studies published up to May 20, 2019, reporting on associations of body-weight fluctuation and mortality from all causes, CVD and cancer, as well as morbidity of CVD and hypertension. Summary relative risks (RRs) were estimated using a random-effects model.Results: Twenty-five eligible publications from 23 studies with 441,199 participants were included. Body-weight fluctuation was associated with increased risk for all-cause mortality (RR, 1.41; 95% confidence interval (CI): 1.27–1.57), CVD mortality (RR, 1.36; 95% CI 1.22–1.52), and morbidity of CVD (RR, 1.49, 95% CI 1.26–1.76) and hypertension (RR, 1.35, 95% CI 1.14–1.61). However, there was no significant association between weight fluctuation and cancer mortality (RR, 1.01; 95% CI 0.90–1.13). No evidence of publication bias was observed (all P > 0.05) except for studies on all-cause mortality (Egger's test, P = 0.001; Begg's test, P = 0.014).Conclusions: Body-weight fluctuation was associated with higher mortality due to all causes and CVD and a higher morbidity of CVD and hypertension.