Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-<i>a</i>]Pyrimidines as New Acetylcholinesterase Inhibitors

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-<i>a</i>]Pyrimidines as New Acetylcholinesterase Inhibitors

A new series of thiazolo[3,2-<i>a</i>]pyrimidine bromide salt derivatives <b>7a</b>−<b>d</b> were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and sing...

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Bibliographic Details
Main Authors:	Mohamed Y. Mahgoub, Awatef M. Elmaghraby, Abd-Elfttah A. Harb, João L. Ferreira da Silva, Gonçalo C. Justino, M. Matilde Marques
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Molecules
Subjects:	thiazolopyrimidines acetylcholinesterase inhibition molecular docking crystal structures
Online Access:	https://www.mdpi.com/1420-3049/24/12/2306

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