Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-<i>a</i>]Pyrimidines as New Acetylcholinesterase Inhibitors

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-<i>a</i>]Pyrimidines as New Acetylcholinesterase Inhibitors

A new series of thiazolo[3,2-<i>a</i>]pyrimidine bromide salt derivatives <b>7a</b>&#8722;<b>d</b> were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and sing...

Full description

Bibliographic Details
Main Authors: Mohamed Y. Mahgoub, Awatef M. Elmaghraby, Abd-Elfttah A. Harb, João L. Ferreira da Silva, Gonçalo C. Justino, M. Matilde Marques
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
thiazolopyrimidines
acetylcholinesterase inhibition
molecular docking
crystal structures
Online Access:https://www.mdpi.com/1420-3049/24/12/2306

Internet

https://www.mdpi.com/1420-3049/24/12/2306

Similar Items