HETEROSUBTYPIC IMMUNE RESPONSE AND CROSS-PROTECTION AGAINST A HIGHLY PATHOGENIC A (H5N1) INFLUENZA VIRUS IN MICE IMMUNIZED WITH COLD-ADAPTED A/LENINGRAD/134/17/57 (H2N2) INFLUENZA VIRUS

HETEROSUBTYPIC IMMUNE RESPONSE AND CROSS-PROTECTION AGAINST A HIGHLY PATHOGENIC A (H5N1) INFLUENZA VIRUS IN MICE IMMUNIZED WITH COLD-ADAPTED A/LENINGRAD/134/17/57 (H2N2) INFLUENZA VIRUS

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While investigating the efficacy of an H5N2 ca reassortant vaccine candidate in protecting against a lethal challenge with a highly pathogenic (HP) H5N1 virus in the mouse model, we observed a degree of cross-protection provided by the ca Len/17 (H2N2) virus itself. 80% of mice administered a high d...

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Bibliographic Details
Main Authors: A. R. Rekstin, J. A. Desheva, X. Lu, G. I. Alexandrova, A. I. Klimov, J. M. Katz, L. G. Rudenko
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
heterosubtypic immunity
live influenza vaccine
avian influenza viruses
Online Access:https://www.mimmun.ru/mimmun/article/view/598

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