Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects

Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects

A model-based approach for the assessment of pathway dynamics is explored to characterize metabolic and signaling pathway activity changes characteristic of the dosing-dependent differences in response to methylprednisolone in muscle. To consistently compare dosing-induced changes we extend the prin...

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Bibliographic Details
Main Authors: Alison Acevedo, Debra DuBois, Richard R. Almon, William J. Jusko, Ioannis P. Androulakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
omics
corticosteroids
pathway analysis
methylprednisolone
dose comparison
tissue comparison
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00759/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00759/full

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