The Danger Theory: Twenty Years Later

The self-nonself theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the danger theory. This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent exper...

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Main Authors:	Thomas ePradeu, Edwin L Cooper
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-09-01
Series:	Frontiers in Immunology
Subjects:	Immunity Inflammation Transplantation Cancer tolerance innate immunity
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00287/full

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spelling	doaj-47e987f2f5e24e54a0327f795b4bdf842020-11-24T23:43:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-09-01310.3389/fimmu.2012.0028731824The Danger Theory: Twenty Years LaterThomas ePradeu0Edwin L Cooper1Sorbonne UniversityUniversity of California, Los AngelesThe self-nonself theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the danger theory. This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00287/fullImmunityInflammationTransplantationCancertoleranceinnate immunity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thomas ePradeu Edwin L Cooper
spellingShingle	Thomas ePradeu Edwin L Cooper The Danger Theory: Twenty Years Later Frontiers in Immunology Immunity Inflammation Transplantation Cancer tolerance innate immunity
author_facet	Thomas ePradeu Edwin L Cooper
author_sort	Thomas ePradeu
title	The Danger Theory: Twenty Years Later
title_short	The Danger Theory: Twenty Years Later
title_full	The Danger Theory: Twenty Years Later
title_fullStr	The Danger Theory: Twenty Years Later
title_full_unstemmed	The Danger Theory: Twenty Years Later
title_sort	danger theory: twenty years later
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2012-09-01
description	The self-nonself theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the danger theory. This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined.
topic	Immunity Inflammation Transplantation Cancer tolerance innate immunity
url	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00287/full
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The Danger Theory: Twenty Years Later

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