Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves’ orbital fibroblasts

Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves’ orbital fibroblasts

Abstract Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. However, it is not clear whether this interaction also takes place in GO. In this study, we investigated the role of CTGF in TGF...

Full description

Bibliographic Details
Main Authors:	Chieh-Chih Tsai, Shi-Bei Wu, Hui-Chuan Kau, Yau-Huei Wei
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-018-25370-3

Similar Items

JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
by: Tzu-Yu Hou, et al.
Published: (2021-03-01)

Alteration of Connective Tissue Growth Factor (CTGF) Expression in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy.
by: Chieh-Chih Tsai, et al.
Published: (2015-01-01)

Curcumin Suppresses TGF-β1-Induced Myofibroblast Differentiation and Attenuates Angiogenic Activity of Orbital Fibroblasts
by: Wei-Kuang Yu, et al.
Published: (2021-06-01)

Fibroblast Growth Factor-1 Suppresses TGF-β-Mediated Myofibroblastic Differentiation of Rat Hepatic Stellate Cells
by: Eva Peterová, et al.
Published: (2017-02-01)

Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.
by: Tirumuru Nagaraja, et al.
Published: (2012-01-01)

Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms
by: Jung-Yeon Kim, et al.
Published: (2020-01-01)

Ets-1 is essential for connective tissue growth factor (CTGF/CCN2) induction by TGF-β1 in osteoblasts.
by: Max T Geisinger, et al.
Published: (2012-01-01)

Thrombin-induced connective tissue growth factor (CTGF/CCN2) expression in human buccal mucosal fibroblasts through TGF-β1 activation
by: Wen-Hsin Lin, et al.
Published: (2015)

Curcumin Inhibits TGF-β-induced CTGF Expression in Human Gingival Fibroblasts
by: Jung-Tsu Chen, et al.
Published: (2010)

Gene Expression of CTGF in Human Dermal Fibroblasts When Exposed to TGF-β and IL-1α
by: Dahlbom, Moa
Published: (2014)

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
by: Zhang LJ, et al.
Published: (2015-08-01)

Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1.
by: Masum M Mia, et al.
Published: (2014-01-01)

Curcumin inhibits transforming growth factor β induced differentiation of mouselung fibroblasts to myofibroblasts
by: Daishun Liu, et al.
Published: (2016-11-01)

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery
by: Wen-Sheng Cheng, et al.
Published: (2020-09-01)

MYH9 Inhibition Suppresses TGF-β1-Stimulated Lung Fibroblast-to-Myofibroblast Differentiation
by: Xionghua Sun, et al.
Published: (2021-01-01)

Transforming Growth Factor-Beta (TGFΒ)-Mediated Post-Transcriptional Regulation of Epithelial-Mesenchymal Transdifferentiation (EMT)
by: Chaudhury, Arindam
Published: (2010)

TGF-β1 induced transdifferentiation of rpe cells is mediated by TAK1.
by: Zeev Dvashi, et al.
Published: (2015-01-01)

The production of fibroblast growth factor 23 is controlled by TGF-β2
by: Martina Feger, et al.
Published: (2017-07-01)

Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1
by: Yuichi Akatsu, et al.
Published: (2019-08-01)

Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β1-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts
by: Jordanna Dally, et al.
Published: (2017-08-01)

A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
by: Li Zhang, et al.
Published: (2011-12-01)

Transforming growth factor-β1 induces angiotensin-converting enzyme synthesis in rat cardiac fibroblasts during their differentiation to myofibroblasts
by: Victor V Petrov, et al.
Published: (2000-12-01)

Transforming Growth Factor-β1 (TGF-β1) Induces Mast Cell Apoptosis
by: Norozian, Farnaz
Published: (2006)

Mechanism of TGF-β1 on the expression of CTGF and type I collagen in hepatic stellate cells.
by: Hui Lin Yang, et al.
Published: (2012)

Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts.
by: Keitaro Omori, et al.
Published: (2016-01-01)

Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation.
by: Yi Zhang, et al.
Published: (2013-01-01)

Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
by: Dai Shuzhen, et al.
Published: (2009-09-01)

Silencing periostin inhibits myofibroblast transdifferentiation of fibrotic buccal mucosal fibroblasts
by: Jyun-Yang Su, et al.
Published: (2021-11-01)

TGFβ1-induced CTGF/CCN2 expression in human buccal mucosal fibroblasts via NOX4/Src signaling pathway
by: Jenny Zwei-Chieng Chang, et al.
Published: (2013)

Galectin-1 promotes oral tumorigenesis and transdifferentiation of myofibroblasts
by: Hsiao-chin Hong, et al.
Published: (2009)

Fenofibrate inhibits TGF‐β‐induced myofibroblast differentiation and activation in human lung fibroblasts in vitro
by: Ryota Kikuchi, et al.
Published: (2021-08-01)

Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation
by: Coram Guevara, et al.
Published: (2021-01-01)

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis
by: Norihiko Sakai, et al.
Published: (2017-07-01)

Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism.
by: Fen Guo, et al.
Published: (2011-01-01)

Relaxin prevents cardiac fibroblast-myofibroblast transition via notch-1-mediated inhibition of TGF-β/Smad3 signaling.
by: Chiara Sassoli, et al.
Published: (2013-01-01)

Retraction: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
by: Dai Shuzhen, et al.
Published: (2009-10-01)

Role of Heat Shock Protein 47 in Transdifferentiation of Human Tenon's Fibroblasts to Myofibroblasts
by: Hong Samin, et al.
Published: (2012-09-01)

Features of the content of transforming growth factors – beta 1,2,3 (TGF-β1, TGF-β2, TGF-β3) in intraocular fluid in primary open-angle glaucoma
by: V. V. Chernykh, et al.
Published: (2019-07-01)

Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
by: Peng Liu, et al.
Published: (2020-02-01)

Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway
by: Harsha Nagar, et al.
Published: (2021-01-01)