Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

Nod-like receptor protein 3 (NLRP3) inflammasome activation has been implicated in the pathogenesis of general anesthesia (GA)-induced neuroinflammation and cognitive impairment in aged rodents. However, the cellular basis for cognitive impairment is still not fully understood, and effective pharmac...

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Bibliographic Details
Main Authors: Yunxia Fan, Liwu Du, Qun Fu, Zhiqiang Zhou, Jingyu Zhang, Guomin Li, Jing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NLRP3
neuroinflammation
pyroptosis
cognitive impairment
general anesthesia
aging
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00426/full

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