5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal

5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal

Abstract.: Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into...

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Main Authors: Yu Ohmura, Emily M. Jutkiewicz, Mitsuhiro Yoshioka, Edward F. Domino
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319306449
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spelling doaj-47d0bd6529cd4caa9be7962e0d23a5b62020-11-25T01:26:22ZengElsevierJournal of Pharmacological Sciences1347-86132011-01-0111721211245-Hydroxytryptophan Attenuates Somatic Signs of Nicotine WithdrawalYu Ohmura0Emily M. Jutkiewicz1Mitsuhiro Yoshioka2Edward F. Domino3Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0632, USA; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, N15W7 Kita-ku, Sapporo, Hokkaido 060-8638, JapanDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0632, USADepartment of Neuropharmacology, Hokkaido University Graduate School of Medicine, N15W7 Kita-ku, Sapporo, Hokkaido 060-8638, JapanDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0632, USA; Corresponding author. efdabcde@umich.eduAbstract.: Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting l-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT. Keywords:: addiction, smoking, tobaccohttp://www.sciencedirect.com/science/article/pii/S1347861319306449
collection DOAJ
language English
format Article
sources DOAJ
author Yu Ohmura
Emily M. Jutkiewicz
Mitsuhiro Yoshioka
Edward F. Domino
spellingShingle Yu Ohmura
Emily M. Jutkiewicz
Mitsuhiro Yoshioka
Edward F. Domino
5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
Journal of Pharmacological Sciences
author_facet Yu Ohmura
Emily M. Jutkiewicz
Mitsuhiro Yoshioka
Edward F. Domino
author_sort Yu Ohmura
title 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
title_short 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
title_full 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
title_fullStr 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
title_full_unstemmed 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
title_sort 5-hydroxytryptophan attenuates somatic signs of nicotine withdrawal
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2011-01-01
description Abstract.: Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting l-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT. Keywords:: addiction, smoking, tobacco
url http://www.sciencedirect.com/science/article/pii/S1347861319306449
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AT emilymjutkiewicz 5hydroxytryptophanattenuatessomaticsignsofnicotinewithdrawal
AT mitsuhiroyoshioka 5hydroxytryptophanattenuatessomaticsignsofnicotinewithdrawal
AT edwardfdomino 5hydroxytryptophanattenuatessomaticsignsofnicotinewithdrawal
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