A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera

A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera

Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of...

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Main Authors: Qin Shu, Diana Catalina Ardila, Ricardo G. Sanfelice, Jonathan P. Vande Geest
Format: Article
Language:English
Published: Open Publishing Association 2013-08-01
Series:Electronic Proceedings in Theoretical Computer Science
Online Access:http://arxiv.org/pdf/1309.0873v1
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spelling doaj-47cdb96d3e2446159650152ded5041cc2020-11-24T21:55:27ZengOpen Publishing AssociationElectronic Proceedings in Theoretical Computer Science2075-21802013-08-01125Proc. HSB 20139910510.4204/EPTCS.125.8A Hybrid Model of a Genetic Regulatory Network in Mammalian ScleraQin ShuDiana Catalina ArdilaRicardo G. SanfeliceJonathan P. Vande GeestMyopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.http://arxiv.org/pdf/1309.0873v1
collection DOAJ
language English
format Article
sources DOAJ
author Qin Shu
Diana Catalina Ardila
Ricardo G. Sanfelice
Jonathan P. Vande Geest
spellingShingle Qin Shu
Diana Catalina Ardila
Ricardo G. Sanfelice
Jonathan P. Vande Geest
A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
Electronic Proceedings in Theoretical Computer Science
author_facet Qin Shu
Diana Catalina Ardila
Ricardo G. Sanfelice
Jonathan P. Vande Geest
author_sort Qin Shu
title A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
title_short A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
title_full A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
title_fullStr A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
title_full_unstemmed A Hybrid Model of a Genetic Regulatory Network in Mammalian Sclera
title_sort hybrid model of a genetic regulatory network in mammalian sclera
publisher Open Publishing Association
series Electronic Proceedings in Theoretical Computer Science
issn 2075-2180
publishDate 2013-08-01
description Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.
url http://arxiv.org/pdf/1309.0873v1
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