The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.

The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.

Influenza A NS1 and NS2 proteins are encoded by the RNA segment 8 of the viral genome. NS1 is a multifunctional protein and a virulence factor while NS2 is involved in nuclear export of viral ribonucleoprotein complexes. A yeast two-hybrid screening strategy was used to identify host factors support...

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Bibliographic Details
Main Authors: Benoît de Chassey, Anne Aublin-Gex, Alessia Ruggieri, Laurène Meyniel-Schicklin, Fabrine Pradezynski, Nathalie Davoust, Thibault Chantier, Lionel Tafforeau, Philippe-Emmanuel Mangeot, Claire Ciancia, Laure Perrin-Cocon, Ralf Bartenschlager, Patrice André, Vincent Lotteau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3701712?pdf=render

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