Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

DNA damage recognition by the nucleotide excision repair pathway requires an initial step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion. This proofreading step is accomplished in eukaryotes by the TFIIH complex. The critical damage recognition...

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Bibliographic Details
Main Authors: Stefanie C Wolski, Jochen Kuper, Petra Hänzelmann, James J Truglio, Deborah L Croteau, Bennett Van Houten, Caroline Kisker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2435149?pdf=render

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