Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy

Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy

Background. Adenine is involved in a variety of cell biological processes and has been explored for pharmacological uses. Its therapeutic use for managing cancer is of great interest. In the present study, we investigated the anticancer effects of adenine and the underlying mechanism in colon cancer...

Full description

Bibliographic Details
Main Authors:	Hsin-Wu Lai, James Cheng-Chung Wei, Hung-Chang Hung, Chun-Che Lin
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2019/9151070

Similar Items

Apple polyphenol inhibits colon carcinoma metastasis via targeting snail binding to focal adhesion kinase
by: Chia-Hung Hung, et al.
Published: (2015)

Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease
by: Huiqi Yuan, et al.
Published: (2021-01-01)

Inhibition of Vascular Smooth Muscle Growth via Signaling Crosstalk between AMP-Activated Protein Kinase and cAMP-Dependent Protein Kinase
by: Joshua Daniel Stone, et al.
Published: (2012-10-01)

Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
by: Peipei Peng, et al.
Published: (2020-04-01)

Apple polyphenol inhibits colon carcinoma metastasis via disrupting Snail binding to focal adhesion kinase
by: Chia-Hung Hung, et al.
Published: (2015-01-01)

Adenine Inhibits the Invasive Potential of DLD-1 Human Colorectal Cancer Cell via the AMPK/FAK Axis
by: Chien-Wei Huang, et al.
Published: (2021-08-01)

Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro
by: Eva Doleželová, et al.
Published: (2021-06-01)

Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
by: Yan Cheng, et al.
Published: (2010-03-01)

Rottlerin Reduces cAMP/CREB-Mediated Melanogenesis via Regulation of Autophagy
by: Nurinanda Prisky Qomaladewi, et al.
Published: (2019-04-01)

AMP-Activated Protein Kinase Mediates the Effect of Leptin on Avian Autophagy in a Tissue-Specific Manner
by: Alissa Piekarski, et al.
Published: (2018-05-01)

Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway
by: Tae Sung Kim, et al.
Published: (2017-06-01)

Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells.
by: Yi-Fang Cheng, et al.
Published: (2015-01-01)

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase
by: Taewon Yuk, et al.
Published: (2018-01-01)

West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development.
by: Shintaro Kobayashi, et al.
Published: (2020-01-01)

Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
by: Hideki Tanaka, et al.
Published: (2020-07-01)

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy
by: Tariq Hussain, et al.
Published: (2019-05-01)

Inhibition of colon cancer cell growth mediated by TSC2
by: Shu-Ting Yu, et al.
Published: (2009)

Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway
by: Wenlin Chen, et al.
Published: (2018-08-01)

The AMP-Activated Protein Kinase KIN10 Is Involved in the Regulation of Autophagy in Arabidopsis
by: Liang Chen, et al.
Published: (2017-07-01)

Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth
by: Hsin-Yuan Chen, et al.
Published: (2017-09-01)

Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases
by: Silvia Vega-Rubín-de-Celis, et al.
Published: (2020-12-01)

6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest
by: Ching-Bin Lin, et al.
Published: (2012-01-01)

Connective Tissue Growth Factor inhibits Cancer Metabolism and Autophagy
by: Wei-Ting Lai, et al.
Published: (2017)

Calcineurin A (Ca) Inhibition Supresses Protein Synthesis Via Amp Dependent Kinase (Ampk).
by: H. Franch, et al.
Published: (2012-06-01)

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase
by: Lin Yu-Hsin, et al.
Published: (2010-04-01)

Mutual Relations between Substituent Effect, Hydrogen Bonding, and Aromaticity in Adenine-Uracil and Adenine-Adenine Base Pairs
by: Paweł A. Wieczorkiewicz, et al.
Published: (2020-08-01)

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways.
by: Zi-Han Tian, et al.
Published: (2018-01-01)

Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors
by: Sanja Aveic, et al.
Published: (2018-04-01)

Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury
by: Matheus Correa-Costa, et al.
Published: (2014-01-01)

Yiqihuoxue Formula Activates Autophagy and Offers Renoprotection in a Rat Model of Adenine-Induced Kidney Disease
by: Chen Hui Xia, et al.
Published: (2019-01-01)

The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.
by: Jung Mi Park, et al.
Published: (2021-06-01)

Effect of benzimidazole on protein synthesis, photophosphorylation and nicotinamide adenine dinucleotide kinase of wheat leaves
by: Pathak, Suman Madhav.
Published: (2013)

Effect of benzimidazole on protein synthesis, photophosphorylation and nicotinamide adenine dinucleotide kinase of wheat leaves
by: Pathak, Suman Madhav.
Published: (2013)

Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma
by: Zhao YY, et al.
Published: (2018-08-01)

Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway
by: Lishan Zhou, et al.
Published: (2020-01-01)

Regulation of Autophagy by Kinases
by: Savitha Sridharan, et al.
Published: (2011-06-01)

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
by: Kevin Bray, et al.
Published: (2012-01-01)

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition
by: Sun Z, et al.
Published: (2018-08-01)

Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy
by: Hsin-Chaio Chou, et al.
Published: (2020-09-01)

Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus
by: Bingxin Chu, et al.
Published: (2020-08-01)