The Potential of the Cyclotide Scaffold for Drug Development
Cyclotides are a novel class of micro-proteins (≈30–40 residues long) with a unique topology containing a head-to-tail cyclized backbone structure further stabilized by three disulfide bonds that form a cystine knot. This unique molecular framework makes them exceptionally stable...
Main Authors: | Julio A. Camarero, Maria Jose Campbell |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/7/2/31 |
Similar Items
-
Host-Defense Activities of Cyclotides
by: David J. Craik
Published: (2012-02-01) -
Cyclotides evolve : Studies on their natural distribution, structural diversity, and activity
by: Park, Sungkyu
Published: (2016) -
Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design
by: Olga Avrutina, et al.
Published: (2012-10-01) -
Optimization of the cyclotide framework to improve cell penetration properties
by: Yen-Hua eHuang, et al.
Published: (2015-02-01) -
Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens
by: Johannes Koehbach, et al.
Published: (2021-06-01)