Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population

• Main Authors: Qi Li, Wenhui Peng, Hailing Li, Jianhui Zhuang, Xuesheng Luo, Yawei Xu
• Format: Article
• Language: English
• Published: BMC 2017-09-01
• Series: BMC Cardiovascular Disorders
• Subjects: Coronary artery disease; Single-nucleotide polymorphisms; rs1333049; rs702548
• Online Access: http://link.springer.com/article/10.1186/s12872-017-0685-0

Abstract Background Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population. Methods All patients came from the east China area and underwent coronary angiography. Rs7025486 and rs1333049 polymorphism were genotyped in 555 patients with CAD and in 480 healthy controls that underwent coronary angiography. Results In Chinese population, the rs7025486 genotype in the case group was no significant different than the control group (P = 0.531).Meanwhile, the rs1333049 SNP has statistically significant (P = 0.006), which was the independent risk factors for CAD (OR1.252, P = 0.039), and consistent with the past studies conclusion. Conclusion Genotype of rs1333049 on chromosome 9p21, but not rs7025486 on chromosome 9q33, is an independent determinant of the incidence of CAD in Chinese population.