Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major isoforms and characterized the full-length isoform containing an N-terminal CXXC domain (Tet3FL). This CXXC domain binds to unmethylated CpGs, but, unexpectedly, its highest affinity is toward 5-carboxylcytosine (...

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Bibliographic Details
Main Authors: Seung-Gi Jin, Zhi-Min Zhang, Thomas L. Dunwell, Matthew R. Harter, Xiwei Wu, Jennifer Johnson, Zheng Li, Jiancheng Liu, Piroska E. Szabó, Qiang Lu, Guo-liang Xu, Jikui Song, Gerd P. Pfeifer
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014850

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http://www.sciencedirect.com/science/article/pii/S2211124715014850

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