Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin

Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin

Reviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the e...

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Main Authors: Radu Silaghi-Dumitrescu, Augustin C. Moţ, Violeta-Florina Scurtu
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Pharmaceuticals
Subjects:
hemoglobin
blood substitute
oxidative stress
Online Access:http://www.mdpi.com/1424-8247/6/7/867
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spelling doaj-47aa727605644b568ec0d0d4dd800e2c2020-11-25T03:54:41ZengMDPI AGPharmaceuticals1424-82472013-07-016786788010.3390/ph6070867Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond HemoglobinRadu Silaghi-DumitrescuAugustin C. MoţVioleta-Florina ScurtuReviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the extent to which these modifications alter the redox reactivity of the proteins, and on ways in which this can be done systematically and purposefully, within the framework of a working hypothesis where redox side-reactions hold an important role in the physiological outcome of experimental transfusions with artificial oxygen carriers.http://www.mdpi.com/1424-8247/6/7/867hemoglobinblood substituteoxidative stress
collection DOAJ
language English
format Article
sources DOAJ
author Radu Silaghi-Dumitrescu
Augustin C. Moţ
Violeta-Florina Scurtu
spellingShingle Radu Silaghi-Dumitrescu
Augustin C. Moţ
Violeta-Florina Scurtu
Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
Pharmaceuticals
hemoglobin
blood substitute
oxidative stress
author_facet Radu Silaghi-Dumitrescu
Augustin C. Moţ
Violeta-Florina Scurtu
author_sort Radu Silaghi-Dumitrescu
title Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
title_short Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
title_full Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
title_fullStr Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
title_full_unstemmed Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity with and Beyond Hemoglobin
title_sort protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin
publisher MDPI AG
series Pharmaceuticals
issn 1424-8247
publishDate 2013-07-01
description Reviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the extent to which these modifications alter the redox reactivity of the proteins, and on ways in which this can be done systematically and purposefully, within the framework of a working hypothesis where redox side-reactions hold an important role in the physiological outcome of experimental transfusions with artificial oxygen carriers.
topic hemoglobin
blood substitute
oxidative stress
url http://www.mdpi.com/1424-8247/6/7/867
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AT augustincmot proteinbasedbloodsubstitutesrecentattemptsatcontrollingprooxidantreactivitywithandbeyondhemoglobin
AT violetaflorinascurtu proteinbasedbloodsubstitutesrecentattemptsatcontrollingprooxidantreactivitywithandbeyondhemoglobin
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