Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

Abstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resu...

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Main Authors: Carmen P. Wong, Urszula T. Iwaniec, Russell T. Turner
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-021-00150-y
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spelling doaj-47a7f24b1d634c50818302d5125708952021-06-20T11:17:48ZengNature Publishing Groupnpj Microgravity2373-80652021-06-01711410.1038/s41526-021-00150-yEvidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space stationCarmen P. Wong0Urszula T. Iwaniec1Russell T. Turner2Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State UniversitySkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State UniversitySkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State UniversityAbstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.https://doi.org/10.1038/s41526-021-00150-y
collection DOAJ
language English
format Article
sources DOAJ
author Carmen P. Wong
Urszula T. Iwaniec
Russell T. Turner
spellingShingle Carmen P. Wong
Urszula T. Iwaniec
Russell T. Turner
Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
npj Microgravity
author_facet Carmen P. Wong
Urszula T. Iwaniec
Russell T. Turner
author_sort Carmen P. Wong
title Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_short Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_fullStr Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full_unstemmed Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_sort evidence for increased thermogenesis in female c57bl/6j mice housed aboard the international space station
publisher Nature Publishing Group
series npj Microgravity
issn 2373-8065
publishDate 2021-06-01
description Abstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.
url https://doi.org/10.1038/s41526-021-00150-y
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AT russelltturner evidenceforincreasedthermogenesisinfemalec57bl6jmicehousedaboardtheinternationalspacestation
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