Increasing the Effectiveness of Pharmacotherapy in Psychiatry by Using a Pharmacological Interaction Database

• Main Authors: Michal Ordak, Tadeusz Nasierowski, Elzbieta Muszynska, Magdalena Bujalska-Zadrozny
• Format: Article
• Language: English
• Published: MDPI AG 2021-05-01
• Series: Journal of Clinical Medicine
• Subjects: pharmacological interaction database; new psychoactive substances
• Online Access: https://www.mdpi.com/2077-0383/10/10/2185

Recent studies have shown that the knowledge of pharmacological interaction databases in global psychiatry is negligible. The frequency of hospitalizations in the case of patients taking new psychoactive substances along with other drugs continues to increase, very often resulting in the need for polypharmacotherapy. The aim of our research was to make members of the worldwide psychiatric community aware of the need to use a pharmacological interaction database in their daily work. The study involved 2146 psychiatrists from around the world. Participants were primarily contacted through the LinkedIn Recruiter website. The surveyed psychiatrists answered 5 questions concerning case reports of patients taking new psychoactive substances along with other drugs. The questions were answered twice, i.e., before and after using the Medscape drug interaction database. The mean percentage of correct answers given by the group of psychiatrists who were studied separately in six individual continents turned out to be statistically significantly higher after using the pharmacological interaction database (<i>p</i> < 0.001). This also applies to providing correct answers separately, i.e., to each of the five questions asked concerning individual case reports (<i>p</i> < 0.001). Before using the drug interaction database, only 14.1% of psychiatrists stated that they knew and used this type of database (<i>p</i> < 0.001). In the second stage of the study, a statistically significant majority of subjects stated that they were interested in using the pharmacological interaction database from that moment on (<i>p</i> < 0.001) and expressed the opinion that it could be effective in everyday work (<i>p</i> < 0.001). Using a pharmacological interaction database in psychiatry can contribute to the effectiveness of pharmacotherapy.