When the Ends Justify the Means: Regulation of Telomere Addition at Double-Strand Breaks in Yeast

When the Ends Justify the Means: Regulation of Telomere Addition at Double-Strand Breaks in Yeast

Telomeres, repetitive sequences located at the ends of most eukaryotic chromosomes, provide a mechanism to replenish terminal sequences lost during DNA replication, limit nucleolytic resection, and protect chromosome ends from engaging in double-strand break (DSB) repair. The ribonucleoprotein telom...

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Bibliographic Details
Main Authors: Remington E. Hoerr, Katrina Ngo, Katherine L. Friedman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
telomere
telomerase
de novo telomere addition
DNA repair
Pif1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.655377/full

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