NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of acinar cells to external stress signals and is considered to be the initial step in pancreatic carcinogenesis. Despite the requirement for oncogenic Kras in pancreatic cancer (PDAC) development, oncogenic K...

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Bibliographic Details
Main Authors:	Elisabeth Hessmann, Jin-San Zhang, Nai-Ming Chen, Marie Hasselluhn, Geou-Yarh Liou, Peter Storz, Volker Ellenrieder, Daniel D. Billadeau, Alexander Koenig
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2016/5272498

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