Research Progress on Regulatory T Cells in Acute Kidney Injury

Research Progress on Regulatory T Cells in Acute Kidney Injury

Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate...

Full description

Bibliographic Details
Main Authors: Yamei Wang, Yuhong Tao
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2015/174164
id doaj-478dcdb0c2a24f69814f102425c5172f
record_format Article
spelling doaj-478dcdb0c2a24f69814f102425c5172f2020-11-24T23:00:36ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/174164174164Research Progress on Regulatory T Cells in Acute Kidney InjuryYamei Wang0Yuhong Tao1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaImmune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI.http://dx.doi.org/10.1155/2015/174164
collection DOAJ
language English
format Article
sources DOAJ
author Yamei Wang
Yuhong Tao
spellingShingle Yamei Wang
Yuhong Tao
Research Progress on Regulatory T Cells in Acute Kidney Injury
Journal of Immunology Research
author_facet Yamei Wang
Yuhong Tao
author_sort Yamei Wang
title Research Progress on Regulatory T Cells in Acute Kidney Injury
title_short Research Progress on Regulatory T Cells in Acute Kidney Injury
title_full Research Progress on Regulatory T Cells in Acute Kidney Injury
title_fullStr Research Progress on Regulatory T Cells in Acute Kidney Injury
title_full_unstemmed Research Progress on Regulatory T Cells in Acute Kidney Injury
title_sort research progress on regulatory t cells in acute kidney injury
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2015-01-01
description Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI.
url http://dx.doi.org/10.1155/2015/174164
work_keys_str_mv AT yameiwang researchprogressonregulatorytcellsinacutekidneyinjury
AT yuhongtao researchprogressonregulatorytcellsinacutekidneyinjury
_version_ 1725641898800971776

Similar Items