Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants

Abstract Objective Recent studies demonstrated cutaneous phosphorylated α synuclein (p‐syn) deposition in idiopathic and some monogenetic Parkinson disease (PD) patients, suggesting synucleinopathy identical to that in the brain. Although the LRRK2 Gly2385Arg (G2385R) variant is a common PD risk fac...

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Bibliographic Details
Main Authors: Jing Yang, Hao Wang, Yanpeng Yuan, Shiheng Fan, Lanjun Li, Chenyang Jiang, Chengyuan Mao, Changhe Shi, Yuming Xu
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51301