Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer

Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer

Abstract Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge. Methods RNA-seq, qPCR, western blot and immunohistochemistry were employed to identify and confirm the high expression of indolet...

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Bibliographic Details
Main Authors: Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
INMT
SMYD3
Prostate cancer castration-resistance
DMT
MSA
MSC
Online Access:https://doi.org/10.1186/s13046-021-02109-z

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