Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.

Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH) and sEH inhibitors are conside...

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Main Authors: Oliver Jung, Felix Jansen, Anja Mieth, Eduardo Barbosa-Sicard, Rainer U Pliquett, Andrea Babelova, Christophe Morisseau, Sung H Hwang, Cindy Tsai, Bruce D Hammock, Liliana Schaefer, Gerd Geisslinger, Kerstin Amann, Ralf P Brandes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2915917?pdf=render

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