The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance

The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance

Abstract Background The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially in non-small cell lung cancer (NSCLC). Main body Suppression of the EGF...

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Bibliographic Details
Main Authors: Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang, Ming-Hsien Chien
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Epidermal growth factor receptor
Reactive oxygen species
NADPH oxidase
Oxidation
Tumor progression
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s13046-018-0728-0

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