A Series of Oleanolic Acid Derivatives as Anti-Hepatitis B Virus Agents: Design, Synthesis, and in Vitro and in Vivo Biological Evaluation

A Series of Oleanolic Acid Derivatives as Anti-Hepatitis B Virus Agents: Design, Synthesis, and in Vitro and in Vivo Biological Evaluation

A series of oleanolic acid derivatives were synthesized by diverse reactions, including the introduction of conjugated alkadiene and epoxy ring moieties formed by means of photosensitized oxidation. Eosin Y was used as photosensitizer during this process. Next the cytotoxicity of the products was ev...

Full description

Bibliographic Details
Main Authors: Wenqiang Yan, Chenze Zhang, Bi Li, Xin Xu, Miao Liang, Shun Gu, Fuhao Chu, Bing Xu, Jian Ren, Penglong Wang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Molecules
Subjects:
oleanolic-acid derivatives
epoxy ring
eosin Y
anti-hepatitis B virus
virus recrudescence
Online Access:http://www.mdpi.com/1420-3049/21/4/402

Internet

http://www.mdpi.com/1420-3049/21/4/402

Similar Items