<i>BRCA</i> Mutations and Breast Cancer Prevention

<i>BRCA</i> Mutations and Breast Cancer Prevention

Women who inherit a deleterious <i>BRCA1</i> or <i>BRCA2</i> mutation face substantially increased risks of developing breast cancer, which is estimated at 70%. Although annual screening with magnetic resonance imaging (MRI) and mammography promotes the earlier detection of t...

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Bibliographic Details
Main Author: Joanne Kotsopoulos
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
<i>BRCA</i>
breast cancer
prevention
Online Access:https://www.mdpi.com/2072-6694/10/12/524
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spelling doaj-476f53ebc3324e23b23754b6c99af2e92020-11-24T21:28:22ZengMDPI AGCancers2072-66942018-12-01101252410.3390/cancers10120524cancers10120524<i>BRCA</i> Mutations and Breast Cancer PreventionJoanne Kotsopoulos0Women’s College Research Institute, Women’s College Hospital, 76 Grenville Street, 6th Floor, Toronto, ON M5S 1B2, CanadaWomen who inherit a deleterious <i>BRCA1</i> or <i>BRCA2</i> mutation face substantially increased risks of developing breast cancer, which is estimated at 70%. Although annual screening with magnetic resonance imaging (MRI) and mammography promotes the earlier detection of the disease, the gold standard for the primary prevention of breast cancer remains bilateral mastectomy. In the current paper, I review the evidence regarding the management of healthy <i>BRCA</i> mutation carriers, including key risk factors and protective factors, and also discuss potential chemoprevention options. I also provide an overview of the key findings from the literature published to date, with a focus on data from studies that are well-powered, and preferably prospective in nature.https://www.mdpi.com/2072-6694/10/12/524<i>BRCA</i>breast cancerprevention
collection DOAJ
language English
format Article
sources DOAJ
author Joanne Kotsopoulos
spellingShingle Joanne Kotsopoulos
<i>BRCA</i> Mutations and Breast Cancer Prevention
Cancers
<i>BRCA</i>
breast cancer
prevention
author_facet Joanne Kotsopoulos
author_sort Joanne Kotsopoulos
title <i>BRCA</i> Mutations and Breast Cancer Prevention
title_short <i>BRCA</i> Mutations and Breast Cancer Prevention
title_full <i>BRCA</i> Mutations and Breast Cancer Prevention
title_fullStr <i>BRCA</i> Mutations and Breast Cancer Prevention
title_full_unstemmed <i>BRCA</i> Mutations and Breast Cancer Prevention
title_sort <i>brca</i> mutations and breast cancer prevention
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2018-12-01
description Women who inherit a deleterious <i>BRCA1</i> or <i>BRCA2</i> mutation face substantially increased risks of developing breast cancer, which is estimated at 70%. Although annual screening with magnetic resonance imaging (MRI) and mammography promotes the earlier detection of the disease, the gold standard for the primary prevention of breast cancer remains bilateral mastectomy. In the current paper, I review the evidence regarding the management of healthy <i>BRCA</i> mutation carriers, including key risk factors and protective factors, and also discuss potential chemoprevention options. I also provide an overview of the key findings from the literature published to date, with a focus on data from studies that are well-powered, and preferably prospective in nature.
topic <i>BRCA</i>
breast cancer
prevention
url https://www.mdpi.com/2072-6694/10/12/524
work_keys_str_mv AT joannekotsopoulos ibrcaimutationsandbreastcancerprevention
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