Relationship of serum HMGB1 and sentinel lymph node detection with tumor marker levels and malignant molecule expression levels in tumor tissue of gastric cancer patients

• Main Authors: Qing-Hao Gong, Yi-Ting Cai, Hai-Qun Chen, Chao-Feng Zhang, Gang Dai, Song-Ming Zhu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-08-01
• Series: Journal of Hainan Medical University
• Subjects: Ggastric cance; High mobility group box 1; Sentinel lymph node biopsy; Tumor marker
• Online Access: http://www.hnykdxxb.com/PDF/201616/29.pdf

Objective: To study the relationship of serum HMGB1 and sentinel lymph node detection with tumor marker levels and malignant molecule expression levels in tumor tissue of gastric cancer patients. Methods: Patients with early gastric cancer were selected as pathology group, healthy volunteers were selected as control group, serum HMGB1, CA72-4, DDK1, TK1, exosome, PG-I and PG-II levels were determined and PGR percentage was calculated, pathology group received intraoperative sentinel lymph node localization and biopsy, tumor tissue was collected and the expression levels of malignant molecules were determined. Results: Serum HMBG1, CA72-4, DDK1, TK1 and exosome levels of pathology group were higher than those of control group, and PGR percentage was lower than that of control group; the higher the serum HMBG1 level in gastric cancer patients, the higher the CA72-4, DDK1, TK1 and exosome levels and the lower the PGR percentage in serum, and the higher the Survivin protein levels and the lower the PTEN, p21, Caspase-3 and Caspase-7 levels in tumor tissue; CA72-4, DDK1, TK1 and exosome levels in serum and Survivin protein level in tumor tissue of patients with SLNS(+) gastric cancer were significantly higher than those of patients with SLNS(-) gastric cancer, and PGR percentage in serum and PTEN, p21, Caspase-3 and Caspase-7 protein levels in tumor tissue were significantly lower than those of patients with SLNS(-) gastric cancer. Conclusion: Serum HMGB1 and sentinel lymph node detection in gastric cancer patients can early assess tumor malignancy and lymph node metastasis.