Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21976-w |
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doaj-4767d9e2f20b432ab88e90cb4777af442021-03-21T12:14:01ZengNature Publishing GroupNature Communications2041-17232021-03-0112112110.1038/s41467-021-21976-wAcetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancerBaotong Zhang0Yixiang Li1Qiao Wu2Lin Xie3Benjamin Barwick4Changying Fu5Xin Li6Daqing Wu7Siyuan Xia8Jing Chen9Wei Ping Qian10Lily Yang11Adeboye O. Osunkoya12Lawrence Boise13Paula M. Vertino14Yichao Zhao15Menglin Li16Hsiao-Rong Chen17Jeanne Kowalski18Omer Kucuk19Wei Zhou20Jin-Tang Dong21Department of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Genetics and Cell Biology, Nankai University College of Life SciencesDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Genetics and Cell Biology, Nankai University College of Life SciencesMolecular Oncology and Biomarkers Program, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta UniversityMolecular Oncology and Biomarkers Program, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta UniversityDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineWinship Cancer Institute, Emory UniversityWinship Cancer Institute, Emory UniversityWinship Cancer Institute, Emory UniversityDepartment of Hematology and Medical Oncology, Emory University School of MedicineWinship Cancer Institute, Emory UniversityDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory UniversityDepartment of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory UniversityDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineDepartment of Hematology and Medical Oncology, Emory University School of MedicineThe therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.https://doi.org/10.1038/s41467-021-21976-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong |
| spellingShingle |
Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer Nature Communications |
| author_facet |
Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong |
| author_sort |
Baotong Zhang |
| title |
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| title_short |
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| title_full |
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| title_fullStr |
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| title_full_unstemmed |
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| title_sort |
acetylation of klf5 maintains emt and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4. |
| url |
https://doi.org/10.1038/s41467-021-21976-w |
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