Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription

Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription

Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress a...

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Bibliographic Details
Main Authors: Chen-Chun Pai, Anastasiya Kishkevich, Rachel S. Deegan, Andrea Keszthelyi, Lisa Folkes, Stephen E. Kearsey, Nagore De León, Ignacio Soriano, Robertus Antonius Maria de Bruin, Antony M. Carr, Timothy C. Humphrey
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
histone methylation
histone H3K36 methylation
DNA replication
MBF
Schizosaccharomyces pombe
Set2
ribonucleotide reductase
dNTP
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731183X

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http://www.sciencedirect.com/science/article/pii/S221112471731183X

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