Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population

• Main Authors: Chang-Hsun Hsieh, Yi-Jen Hung, Dee Pei, et al
• Format: Article
• Language: English
• Published: Dove Medical Press 2010-03-01
• Series: The Application of Clinical Genetics
• Online Access: http://www.dovepress.com/pilot-study-of-an-association-between-a-common-variant-in-the-non-musc-a4093
• ISSN: 1178-704X

Chang-Hsun Hsieh1, Yi-Jen Hung1, Dee Pei2, Shi-Wen Kuo3, Eugene Lin41Division of Endocrinology and Metabolism, Tri-Service General Hospital, Taipei; 2Division of Endocrinology and Metabolism, Cardinal Tien Hospital, Taipei County; 3Division of Endocrinology, Buddhist Xindian Tzu Chi General Hospital, Taipei; 4Vita Genomics Inc., Wugu Shiang, Taipei, TaiwanAbstract: Nowadays diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). Recent studies have demonstrated that the myosin, heavy chain 9, non-muscle (MYH9) gene is associated with ESRD in African Americans. In this study, we tested the hypothesis that a common single nucleotide polymorphism rs16996677 in the MYH9 gene may contribute to the etiology of DN in type 2 diabetes (T2D) in a Taiwanese population with T2D. There were 180 T2D patients diagnosed with DN and 178 age- and sex-similar T2D without DN controls. Single locus analyses showed no significant main effects of MYH9 rs16996677 on the risk of DN in T2D. The results suggest that the rs16996677 SNP in MYH9 may not contribute to the risk of DN in T2D in Taiwanese T2D patients.Keywords: diabetic nephropathy, end-stage renal disease, single nucleotide polymorphisms, type 2 diabetes