Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

<p>Abstract</p> <p>Background</p> <p>Estrogen acts on the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ER)β-dependent mechanism. We investigated in the present study nontr...

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Bibliographic Details
Main Authors: Wu Kay LH, Chen Chen-Hsiu, Shih Cheng-Dean
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Journal of Biomedical Science
Subjects:
17β-estradiol
Estrogen receptor
Rostral ventrolateral medulla
Systemic arterial pressure
PI3K/Akt signaling pathway
Online Access:http://www.jbiomedsci.com/content/19/1/76

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