HLH-11 modulates lipid metabolism in response to nutrient availability

HLH-11 modulates lipid metabolism in response to nutrient availability

Organismal metabolism fluctuates depending on nutritional conditions. Here, the authors show that, in C. elegans, HLH-11 negatively regulates lipid metabolism genes in the presence of nutrients and that its abundance decreased in response to starvation, thereby promoting fat utilization.

Bibliographic Details
Main Authors: Yi Li, Wanqiu Ding, Chuan-Yun Li, Ying Liu
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19754-1
id doaj-474e3a91eed844a582555d962edcc99b
record_format Article
spelling doaj-474e3a91eed844a582555d962edcc99b2021-01-31T12:55:31ZengNature Publishing GroupNature Communications2041-17232020-11-0111111310.1038/s41467-020-19754-1HLH-11 modulates lipid metabolism in response to nutrient availabilityYi Li0Wanqiu Ding1Chuan-Yun Li2Ying Liu3State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking UniversityLaboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking UniversityLaboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking UniversityState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking UniversityOrganismal metabolism fluctuates depending on nutritional conditions. Here, the authors show that, in C. elegans, HLH-11 negatively regulates lipid metabolism genes in the presence of nutrients and that its abundance decreased in response to starvation, thereby promoting fat utilization.https://doi.org/10.1038/s41467-020-19754-1
collection DOAJ
language English
format Article
sources DOAJ
author Yi Li
Wanqiu Ding
Chuan-Yun Li
Ying Liu
spellingShingle Yi Li
Wanqiu Ding
Chuan-Yun Li
Ying Liu
HLH-11 modulates lipid metabolism in response to nutrient availability
Nature Communications
author_facet Yi Li
Wanqiu Ding
Chuan-Yun Li
Ying Liu
author_sort Yi Li
title HLH-11 modulates lipid metabolism in response to nutrient availability
title_short HLH-11 modulates lipid metabolism in response to nutrient availability
title_full HLH-11 modulates lipid metabolism in response to nutrient availability
title_fullStr HLH-11 modulates lipid metabolism in response to nutrient availability
title_full_unstemmed HLH-11 modulates lipid metabolism in response to nutrient availability
title_sort hlh-11 modulates lipid metabolism in response to nutrient availability
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Organismal metabolism fluctuates depending on nutritional conditions. Here, the authors show that, in C. elegans, HLH-11 negatively regulates lipid metabolism genes in the presence of nutrients and that its abundance decreased in response to starvation, thereby promoting fat utilization.
url https://doi.org/10.1038/s41467-020-19754-1
work_keys_str_mv AT yili hlh11modulateslipidmetabolisminresponsetonutrientavailability
AT wanqiuding hlh11modulateslipidmetabolisminresponsetonutrientavailability
AT chuanyunli hlh11modulateslipidmetabolisminresponsetonutrientavailability
AT yingliu hlh11modulateslipidmetabolisminresponsetonutrientavailability
_version_ 1724317068497518592

Similar Items