Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation

Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phyl...

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Main Authors:	C. Sharma, N. Kumar, R. Pandey, J.F. Meis, A. Chowdhary
Format:	Article
Language:	English
Published:	Elsevier 2016-09-01
Series:	New Microbes and New Infections
Subjects:	Candida auris India multidrug resistant outbreak whole genome sequencing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2052297516300749

id	doaj-470def9b20934ae8b79a71f66e6dbbaf
record_format	Article
spelling	doaj-470def9b20934ae8b79a71f66e6dbbaf2020-11-25T00:08:54ZengElsevierNew Microbes and New Infections2052-29752016-09-0113C778210.1016/j.nmni.2016.07.003Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variationC. Sharma0N. Kumar1R. Pandey2J.F. Meis3A. Chowdhary4Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaWellcome Trust Sanger Institute, Hinxton, UKCSIR Ayurgenomics Unit-TRISUTRA, Council of Scientific & Industrial Research–Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, IndiaDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsDepartment of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaCandida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).http://www.sciencedirect.com/science/article/pii/S2052297516300749Candida aurisIndiamultidrug resistantoutbreakwhole genome sequencing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	C. Sharma N. Kumar R. Pandey J.F. Meis A. Chowdhary
spellingShingle	C. Sharma N. Kumar R. Pandey J.F. Meis A. Chowdhary Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation New Microbes and New Infections Candida auris India multidrug resistant outbreak whole genome sequencing
author_facet	C. Sharma N. Kumar R. Pandey J.F. Meis A. Chowdhary
author_sort	C. Sharma
title	Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_short	Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_full	Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_fullStr	Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_full_unstemmed	Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_sort	whole genome sequencing of emerging multidrug resistant candida auris isolates in india demonstrates low genetic variation
publisher	Elsevier
series	New Microbes and New Infections
issn	2052-2975
publishDate	2016-09-01
description	Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).
topic	Candida auris India multidrug resistant outbreak whole genome sequencing
url	http://www.sciencedirect.com/science/article/pii/S2052297516300749
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Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation

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