Rhein Induces Cell Death in HepaRG Cells through Cell Cycle Arrest and Apoptotic Pathway

Rhein Induces Cell Death in HepaRG Cells through Cell Cycle Arrest and Apoptotic Pathway

Rhein, a naturally occurring active anthraquinone found abundantly in various medicinal and nutritional herbs, possesses a wide spectrum of pharmacological effects. Furthermore, previous studies have reported that rhein could induce hepatotoxicity in rats. However, its cytotoxicity and potential mol...

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Bibliographic Details
Main Authors: Longtai You, Xiaoxv Dong, Xingbin Yin, Chunjing Yang, Xin Leng, Wenping Wang, Jian Ni
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
rhein
hepatotoxicity
HepaRG cells
ROS
apoptosis
Online Access:http://www.mdpi.com/1422-0067/19/4/1060

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