Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films

Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films

Febuxostat (FXS) is a potent antigout drug with poor water solubility and relative high first-pass effect leading to moderate oral bioavailability (<49%). This study aimed to increase FXS solubility and bioavailability by optimizing sublingual fast-dissolving films (SFs) containing a selected FXS...

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Bibliographic Details
Main Authors: Basant A. Habib, Amina S. Abd El-Samiae, Boushra M. El-Houssieny, Randa Tag
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
febuxostat self-nano-emulsions
sublingual films
patient-wise convenient formula
full factorial design
sequence effect in cross over data
Online Access:http://dx.doi.org/10.1080/10717544.2021.1927247

Internet

http://dx.doi.org/10.1080/10717544.2021.1927247

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