Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

Accurate detection of TADs requires ultra-deep sequencing and sophisticated normalisation procedures, which limits the analysis of Hi-C data. Here the authors develop a normalisation-free method to decode the domains of chromosomes (deDoc) that utilizes structural entropy to predict TADs with ultra-...

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Bibliographic Details
Main Authors: Angsheng Li, Xianchen Yin, Bingxiang Xu, Danyang Wang, Jimin Han, Yi Wei, Yun Deng, Ying Xiong, Zhihua Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05691-7

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