Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Replication stress has been associated with transient remodelling of replication intermediates into reversed forks, followed by efficient fork restart. Here the authors systematically analyse the role of RAD51 paralogs in these transactions, providing insights on the mechanistic role of different co...

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Main Authors:	Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A. Schmid, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17324-z

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spelling	doaj-46eeddebb333460895c7cc3055c262ef2021-07-18T11:45:12ZengNature Publishing GroupNature Communications2041-17232020-07-0111111210.1038/s41467-020-17324-zSequential role of RAD51 paralog complexes in replication fork remodeling and restartMatteo Berti0Federico Teloni1Sofija Mijic2Sebastian Ursich3Jevgenij Fuchs4Maria Dilia Palumbieri5Jana Krietsch6Jonas A. Schmid7Edwige B. Garcin8Stéphanie Gon9Mauro Modesti10Matthias Altmeyer11Massimo Lopes12Institute of Molecular Cancer Research, University of ZurichDepartment of Molecular Mechanisms of Disease, University of ZurichInstitute of Molecular Cancer Research, University of ZurichInstitute of Molecular Cancer Research, University of ZurichInstitute of Molecular Cancer Research, University of ZurichInstitute of Molecular Cancer Research, University of ZurichInstitute of Molecular Cancer Research, University of ZurichInstitute of Molecular Cancer Research, University of ZurichCancer Research Center of Marseille; CNRS; Inserm; Institut Paoli-Calmettes; Aix-Marseille UniversitéCancer Research Center of Marseille; CNRS; Inserm; Institut Paoli-Calmettes; Aix-Marseille UniversitéCancer Research Center of Marseille; CNRS; Inserm; Institut Paoli-Calmettes; Aix-Marseille UniversitéDepartment of Molecular Mechanisms of Disease, University of ZurichInstitute of Molecular Cancer Research, University of ZurichReplication stress has been associated with transient remodelling of replication intermediates into reversed forks, followed by efficient fork restart. Here the authors systematically analyse the role of RAD51 paralogs in these transactions, providing insights on the mechanistic role of different complexes of these proteins.https://doi.org/10.1038/s41467-020-17324-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matteo Berti Federico Teloni Sofija Mijic Sebastian Ursich Jevgenij Fuchs Maria Dilia Palumbieri Jana Krietsch Jonas A. Schmid Edwige B. Garcin Stéphanie Gon Mauro Modesti Matthias Altmeyer Massimo Lopes
spellingShingle	Matteo Berti Federico Teloni Sofija Mijic Sebastian Ursich Jevgenij Fuchs Maria Dilia Palumbieri Jana Krietsch Jonas A. Schmid Edwige B. Garcin Stéphanie Gon Mauro Modesti Matthias Altmeyer Massimo Lopes Sequential role of RAD51 paralog complexes in replication fork remodeling and restart Nature Communications
author_facet	Matteo Berti Federico Teloni Sofija Mijic Sebastian Ursich Jevgenij Fuchs Maria Dilia Palumbieri Jana Krietsch Jonas A. Schmid Edwige B. Garcin Stéphanie Gon Mauro Modesti Matthias Altmeyer Massimo Lopes
author_sort	Matteo Berti
title	Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
title_short	Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
title_full	Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
title_fullStr	Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
title_full_unstemmed	Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
title_sort	sequential role of rad51 paralog complexes in replication fork remodeling and restart
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Replication stress has been associated with transient remodelling of replication intermediates into reversed forks, followed by efficient fork restart. Here the authors systematically analyse the role of RAD51 paralogs in these transactions, providing insights on the mechanistic role of different complexes of these proteins.
url	https://doi.org/10.1038/s41467-020-17324-z
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Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

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