Effect of different walking break strategies on superficial femoral artery endothelial function

Abstract Breaking up prolonged sitting with physical activity (PA) breaks prevents conduit artery dysfunction. However, the optimal break strategy to achieve this, in terms of the frequency or duration of PA, is not known. This study assessed the effect of breaking up sitting with different PA break...

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Main Authors: Sophie E. Carter, Richard Draijer, Sophie M. Holder, Louise Brown, Dick H. J. Thijssen, Nicola D. Hopkins
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14190
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spelling doaj-46ec8d532a9242978d8267270bccf33e2020-11-25T02:59:45ZengWileyPhysiological Reports2051-817X2019-08-01716n/an/a10.14814/phy2.14190Effect of different walking break strategies on superficial femoral artery endothelial functionSophie E. Carter0Richard Draijer1Sophie M. Holder2Louise Brown3Dick H. J. Thijssen4Nicola D. Hopkins5Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United KingdomUnilever Research and Development Vlaardingen The NetherlandsResearch Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United KingdomUnilever Research and Development Bedfordshire United KingdomResearch Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United KingdomResearch Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United KingdomAbstract Breaking up prolonged sitting with physical activity (PA) breaks prevents conduit artery dysfunction. However, the optimal break strategy to achieve this, in terms of the frequency or duration of PA, is not known. This study assessed the effect of breaking up sitting with different PA break strategies on lower limb peripheral artery endothelial function. Fifteen participants (10 male, 35.8 ± 10.2 years, BMI: 25.5 ± 3.2 kg m−2) completed, on separate days, three 4‐h conditions in a randomized order: (1) uninterrupted sitting (SIT), (2) sitting with 2‐min light‐intensity walking breaks every 30 min (2WALK), or (3) sitting with 8‐min light‐intensity walking breaks every 2 h (8WALK). At baseline and 4 h, superficial femoral artery function (flow‐mediated dilation; FMD), blood flow, and shear rate (SR) were assessed using Doppler ultrasound. For each condition, the change in outcome variables was calculated and data were statistically analyzed using a linear mixed model. There was no significant main effect for the change in FMD (P = 0.564). A significant main effect was observed for the change in blood flow (P = 0.022), with post hoc analysis revealing a greater reduction during SIT (−42.7 ± 14.2 mL·min) compared to 8WALK (0.45 ± 17.7 mL·min; P = 0.012). There were no significant main effects for mean, antegrade, or retrograde SR (P > 0.05). Superficial femoral artery blood flow, but not FMD, was reduced following uninterrupted sitting. This decline in blood flow was prevented with longer duration, less frequent walking breaks rather than shorter, more frequent breaks suggesting the dose (duration and frequency) of PA may influence the prevention of sitting‐induced decreases in blood flow.https://doi.org/10.14814/phy2.14190Blood flowflow‐mediated dilationphysical activity breakssedentary behaviorshear rate
collection DOAJ
language English
format Article
sources DOAJ
author Sophie E. Carter
Richard Draijer
Sophie M. Holder
Louise Brown
Dick H. J. Thijssen
Nicola D. Hopkins
spellingShingle Sophie E. Carter
Richard Draijer
Sophie M. Holder
Louise Brown
Dick H. J. Thijssen
Nicola D. Hopkins
Effect of different walking break strategies on superficial femoral artery endothelial function
Physiological Reports
Blood flow
flow‐mediated dilation
physical activity breaks
sedentary behavior
shear rate
author_facet Sophie E. Carter
Richard Draijer
Sophie M. Holder
Louise Brown
Dick H. J. Thijssen
Nicola D. Hopkins
author_sort Sophie E. Carter
title Effect of different walking break strategies on superficial femoral artery endothelial function
title_short Effect of different walking break strategies on superficial femoral artery endothelial function
title_full Effect of different walking break strategies on superficial femoral artery endothelial function
title_fullStr Effect of different walking break strategies on superficial femoral artery endothelial function
title_full_unstemmed Effect of different walking break strategies on superficial femoral artery endothelial function
title_sort effect of different walking break strategies on superficial femoral artery endothelial function
publisher Wiley
series Physiological Reports
issn 2051-817X
publishDate 2019-08-01
description Abstract Breaking up prolonged sitting with physical activity (PA) breaks prevents conduit artery dysfunction. However, the optimal break strategy to achieve this, in terms of the frequency or duration of PA, is not known. This study assessed the effect of breaking up sitting with different PA break strategies on lower limb peripheral artery endothelial function. Fifteen participants (10 male, 35.8 ± 10.2 years, BMI: 25.5 ± 3.2 kg m−2) completed, on separate days, three 4‐h conditions in a randomized order: (1) uninterrupted sitting (SIT), (2) sitting with 2‐min light‐intensity walking breaks every 30 min (2WALK), or (3) sitting with 8‐min light‐intensity walking breaks every 2 h (8WALK). At baseline and 4 h, superficial femoral artery function (flow‐mediated dilation; FMD), blood flow, and shear rate (SR) were assessed using Doppler ultrasound. For each condition, the change in outcome variables was calculated and data were statistically analyzed using a linear mixed model. There was no significant main effect for the change in FMD (P = 0.564). A significant main effect was observed for the change in blood flow (P = 0.022), with post hoc analysis revealing a greater reduction during SIT (−42.7 ± 14.2 mL·min) compared to 8WALK (0.45 ± 17.7 mL·min; P = 0.012). There were no significant main effects for mean, antegrade, or retrograde SR (P > 0.05). Superficial femoral artery blood flow, but not FMD, was reduced following uninterrupted sitting. This decline in blood flow was prevented with longer duration, less frequent walking breaks rather than shorter, more frequent breaks suggesting the dose (duration and frequency) of PA may influence the prevention of sitting‐induced decreases in blood flow.
topic Blood flow
flow‐mediated dilation
physical activity breaks
sedentary behavior
shear rate
url https://doi.org/10.14814/phy2.14190
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