The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.

Bibliographic Details
Main Authors: V. Barra, D. Fachinetti
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06545-y
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spelling doaj-46e6354e186b4bcfbebd09f24d95c2552021-05-11T09:31:16ZengNature Publishing GroupNature Communications2041-17232018-10-019111710.1038/s41467-018-06545-yThe dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNAV. Barra0D. Fachinetti1Institut Curie, PSL Research University, CNRS, UMR 144Institut Curie, PSL Research University, CNRS, UMR 144Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.https://doi.org/10.1038/s41467-018-06545-y
collection DOAJ
language English
format Article
sources DOAJ
author V. Barra
D. Fachinetti
spellingShingle V. Barra
D. Fachinetti
The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
Nature Communications
author_facet V. Barra
D. Fachinetti
author_sort V. Barra
title The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_short The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_full The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_fullStr The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_full_unstemmed The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_sort dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric dna
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.
url https://doi.org/10.1038/s41467-018-06545-y
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AT dfachinetti darksideofcentromerestypescausesandconsequencesofstructuralabnormalitiesimplicatingcentromericdna
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