The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

Objective: We aimed to determine the effect of human SH2B1 variants on leptin and insulin signaling, which are major regulators of energy homeostasis, on the RNA level. Methods: We analyzed the expression of infrequent alleles of seven SH2B1 variants (Arg67Cys, Lys150Arg, Thr175Ala, Thr343Met, Thr48...

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Bibliographic Details
Main Authors: Johanna Giuranna, Anna-Lena Volckmar, Anna Heinen, Triinu Peters, Börge Schmidt, Anne Spieker, Helena Straub, Harald Grallert, Timo D. Müller, Jochen Antel, Ute Haußmann, Hans Klafki, Rui Liangyou, Johannes Hebebrand, Anke Hinney
Format: Article
Language:English
Published: Karger Publishers 2018-04-01
Series:Obesity Facts
Subjects:
GWAS
SH2B1
JAK
STAT
IRS
Expression genome-wide
Locus
Online Access:https://www.karger.com/Article/FullText/486962

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